Physician Assistant Practice Test I Sample Physician Assistant National Certifying Exam (PANCE) Progress Indicator: Question 1 of 20 1.  Which of the following factors in patients with chronic venous insufficiency predisposes them to development of skin ulcers? Choices: Increased intravascular oncotic pressure Leakage of fibrinogen and growth factors into the interstitial space Decreased capillary leakage Inherited deficiency of protein C